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\u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007\u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad<\/div>\n<center>\n<table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" height=\"100%\" width=\"100%\" id=\"bodyTable\" style=\"background-color: rgb(0, 161, 216);\">\n<tbody><tr>\n<td class=\"bodyCell\" align=\"center\" valign=\"top\">\n<table id=\"root\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\"><tbody data-block-id=\"4\" class=\"mceWrapper\"><tr><td style=\"background-color:transparent\" valign=\"top\" align=\"center\" class=\"mceSectionHeader\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"max-width:660px\" role=\"presentation\"><tbody><tr><td style=\"background-color:#ffffff\" valign=\"top\" class=\"mceWrapperInner\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"3\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" 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style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\"><\/td><\/tr><\/tbody><\/table><\/a><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><tbody data-block-id=\"19\" class=\"mceWrapper\"><tr><td style=\"background-color:transparent\" valign=\"top\" align=\"center\" class=\"mceSectionBody\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"max-width:660px\" role=\"presentation\"><tbody><tr><td style=\"background-color:#ffffff\" valign=\"top\" class=\"mceWrapperInner\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"18\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" 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width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><\/colgroup><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId-125\" data-block-id=\"125\" colspan=\"8\" width=\"66.66666666666666%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-122\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b122\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"122\" class=\"mceText\" id=\"d122\" style=\"width:100%\"><h2><\/h2><h2 class=\"last-child\"><span style=\"font-size: 15px\"><span style=\"font-family: 'DM Sans', sans-serif\">Welcome the 4th\u00a0newsletter (NewsPepper) from Pepper in 2025. We provide updates on our activities and general important issues in the world of Endocrine Disruption sciences. <\/span><\/span><\/h2><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId-127\" data-block-id=\"127\" colspan=\"4\" width=\"33.33333333333333%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-87\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b87\"><table width=\"100%\" style=\"border:0;background-color:#f5f7f9;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"87\" class=\"mceText\" id=\"d87\" style=\"width:100%\"><p><strong><span style=\"color:#222328;\"><span style=\"font-size: 12px\">Summary<\/span><\/span><\/strong><\/p><p><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 1. Recap 2025<\/span><\/span><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%;\"><br><\/p><p class=\"mcePastedContent\"><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 2. Policy news<\/span><\/span><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%;\"><br><\/p><p class=\"mcePastedContent\"><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 3. Scientific conferences and consortia<br> \u00a0 \u00a04. The Pepper pipeline<\/span><\/span><\/p><p class=\"mcePastedContent\"><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 \u00a05. The Pepper business<\/span><\/span><\/p><p class=\"mcePastedContent\"><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 \u00a06. A look toward 2026<\/span><\/span><\/p><p class=\"mcePastedContent last-child\"><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 \u00a07. Namwise updates<\/span><\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-44\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b44\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"44\" id=\"section_7b6f2a520fb7b5b4387ba3b558ec9efa\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--22\" data-block-id=\"-22\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" align=\"center\" id=\"b-8\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-8\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--28\" data-block-id=\"-28\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" id=\"b49\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"49\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId-46\" data-block-id=\"46\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-27\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b27\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"27\" class=\"mceText\" id=\"d27\" style=\"width:100%\"><h1 class=\"last-child\">Recap 2025<\/h1><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-88\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b88\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"88\" class=\"mceText\" id=\"d88\" style=\"width:100%\"><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">The year 2025 has in many ways been extraordinary for Pepper. This was the year with real breakthroughs with respect to method validation and dissemination. We have submitted <\/span><\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-size: 16px\"><span style=\"font-family: 'DM Sans', sans-serif\">the first draft test guideline<\/span><\/span><\/span><\/strong><span style=\"color:#00a1d8;\"><span style=\"font-size: 16px\"><span style=\"font-family: 'DM Sans', sans-serif\"> <\/span><\/span><\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-size: 16px\"><span style=\"font-family: 'DM Sans', sans-serif\">to OECD<\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\"> <\/span><\/span><\/strong><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">and <\/span><\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-size: 16px\"><span style=\"font-family: 'DM Sans', sans-serif\">published the first scientific article covering this successful validation project<\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">.<\/span><\/span><\/strong><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\"> The second method validation report was submitted for peer review under OECD and a manuscript for this project was also submitted for publication. The Pepper pipeline is maturing significantly at the moment, and we foresee more submissions in 2026 to both OECD and scientific journals.<\/span><\/span><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00a0<\/span><\/span><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">It was also the year when we said goodbye to our founding Director Philippe Hubert that was the locomotive in establishing Pepper and its supporting committees. Philippe could retire with the knowledge that Pepper has evolved into an international (4 countries are represented in the team) professional method validation unit with contacts and support throughout the European community of Endocrine Disruption research and beyond. We also welcomed and had to say goodbye to Celine Boudet as Director, coming from INERIS (L’Institut national de l’environnement industriel et des risques, FR) with a wealth of experience in environmental toxicology and large research projects, Celine was also involved when Pepper was initiated six years ago out of an INERIS project. Celine made a big impact on the new business model for Pepper and managed to influence the organization in a comprehensive way. However, she decided to go back to INERIS where she has worked for many years close to research with environmental impact.<\/span><\/span><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00a0<\/span><\/span><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">A key new step for Pepper was the <\/span><\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-size: 16px\"><span style=\"font-family: 'DM Sans', sans-serif\">signing of a formal collaboration agreement with BfR<\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\"> <\/span><\/span><\/strong><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">(The German Federal Institute for Risk Assessment) the German counterpart of INERIS. In this agreement we support each other on specific validation projects and share experiences, while BfR builds a validation effort themselves. We already collaborate in specific projects and have regular exchanges of ideas and information.<\/span><\/span><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00a0<\/span><\/span><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">Lastly, 2025 was the year when a Pepper team member became a parent for the first time. On Tuesday the 14<\/span><\/span><sup><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">th<\/span><\/span><\/sup><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\"> of October Andrea gave birth to a healthy baby girl and the whole team congratulates her and the family. Andrea will return to action at Pepper in 2026.<\/span><\/span><\/p><p style=\"text-align: left;\" class=\"last-child\"><br><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b142\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-142\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/b71fc02d-e36e-6a59-a255-72d77ba51169.png\" width=\"628\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"142\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-129\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b129\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"129\" class=\"mceText\" id=\"d129\" style=\"width:100%\"><h1 class=\"last-child\">Policy News<\/h1><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-130\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b130\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"130\" class=\"mceText\" id=\"d130\" style=\"width:100%\"><h4 style=\"text-align: left;\">EU provisional agreement to update water-pollutant priority lists: PFAS, bisphenols, pesticides included<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">On 23 September 2025, Council of the EU and European Parliament reached a provisional deal to revise the list of \u201cpriority pollutants\u201d for surface- and groundwater. The updated list adds PFAS (including TFA), certain bisphenols, pesticides, pharmaceuticals and more. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">This revision strengthens environmental-quality standards, updates norms, and aims to align regulation with latest scientific evidence. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">Member States will have until 2039 (or under certain conditions until 2045) to comply fully; for some substances, deadlines may be earlier (e.g. 2033) depending on new standards. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h4 style=\"text-align: left;\">European Chemicals Agency (ECHA) advances PFAS restrictions under REACH & call from endocrine-health societies<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: Symbol\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: "Times New Roman"\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/span><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\"> <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">In October 2025, ECHA announced that its \u201cSocio-Economic Analysis Committee\u201d (SEAC) would issue its draft opinion on the revised PFAS restriction proposal \u2014 a necessary step before final ban decisions. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">On October 30, key medical bodies \u2014 European Society of Endocrinology (ESE), European Society for Paediatric Endocrinology (ESPE), and Endocrine Society \u2014 jointly urged regulators to adopt a universal PFAS restriction, emphasizing health risks and the need to phase out PFAS where safer alternatives exist.<\/span><\/span><\/p><p style=\"text-align: left;\"><strong> \u00a0<\/strong><\/p><h4 style=\"text-align: left;\">Evidence PFAS exposure may cause endocrine disruption in women<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: Symbol\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: "Times New Roman"\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0<\/span><\/span><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">A recent study (Dec 2025) <\/span><\/span><span style=\"font-size: 10.5pt\"><span style=\"font-family: 'DM Sans', sans-serif\">published the \u00a0medical journal \u00a0JAMA Network Open<\/span><\/span><span style=\"color:rgb(26, 27, 27);\"><span style=\"font-size: 10.5pt\"><span style=\"font-family: 'DM Sans', sans-serif\"> <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">found that high PFAS exposure in women is associated with altered hormone profiles \u2014 reinforcing concerns about PFAS as endocrine disruptors.<\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">This strengthens calls from health & endocrine societies for stricter regulation and accelerated removal of PFAS from consumer products and the environment. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%;\"><br><\/p><h4 class=\"mcePastedContent\" style=\"text-align: left;\">ANSES confirms widespread PFAS in French tap water<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%;\"><br><\/p><p class=\"mcePastedContent\" style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">A major nationwide study (2023\u20132025) by ANSES found that 92 % of tap-water samples tested positive for a PFAS breakdown product, trifluoroacetic acid (TFA). <\/span><\/span><\/p><p class=\"mcePastedContent\" style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">Beyond the 20 PFAS covered by the EU drinking-water directive, the agency also detected other PFAS and calls for a broader monitoring scheme. <\/span><\/span><\/p><p class=\"mcePastedContent\" style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">The findings are a wake-up call for regulators: many PFAS remain unmonitored despite pervasive presence. <\/span><\/span><\/p><p><br><\/p><h4 style=\"text-align: left;\">European Chemicals Agency (ECHA) & Organisation for Economic Co-operation and Development (OECD) \u2014 Update of QSAR Toolbox and support for non-animal hazard assessment methods<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: Symbol\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: "Times New Roman"\"><span style=\"font-weight:normal;\">\u00a0\u00a0<\/span><\/span><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">On 8 October 2025, a new version of the OECD QSAR Toolbox (4.8) was released. The update includes enhancements to structural data import, metabolism databases, and improved transparency and security. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">The upgraded toolbox supports computational predictions of chemical hazards, which can help avoid or reduce animal testing \u2014 aligning with ambitions of non-animal methods for endocrine disruptor (ED) assessment.<\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h4 style=\"text-align: left;\">Sant\u00e9 publique France \u2014 New national health-surveillance program on exposures and effects of endocrine disruptors<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: Symbol\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: "Times New Roman"\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">On 7 November 2025, Sant\u00e9 publique France published a design for a health-surveillance program focused on the health effects of exposure to endocrine disruptors (EDs). The program prioritizes certain health outcomes (e.g. neurodevelopmental disorders in children, metabolic issues, reproductive health). <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\" class=\"last-child\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">This marks a stepping stone toward what may feed into the upcoming second National Strategy on Endocrine Disruptors (Strat\u00e9gie nationale sur les perturbateurs endocriniens \u2013 SNPE2), reinforcing monitoring at population level. <\/span><\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:20px;padding-bottom:20px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceDividerBlockContainer\" id=\"b36\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"background-color:transparent;width:100%\" role=\"presentation\" class=\"mceDividerContainer\" data-block-id=\"36\"><tbody><tr><td style=\"min-width:100%;border-top-width:2px;border-top-style:dotted;border-top-color:#d3e2ff;line-height:0;font-size:0\" valign=\"top\" class=\"mceDividerBlock\">\u00a0<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-97\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b97\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"97\" class=\"mceText\" id=\"d97\" style=\"width:100%\"><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h1 style=\"text-align: left;\">Scientific conferences and consortia<\/h1><h1 style=\"text-align: left;\"><\/h1><h4 style=\"text-align: left;\"><span style=\"font-family: 'DM Sans', sans-serif\">American Society of Toxicology (SOT) 2025<\/span><\/h4><p style=\"text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Peppers is being recognized for its work in the validation of methods and bridging a significant gap in non-animal methods (NAMs) to bring these into the test guideline system and regulatory use. Director Philippe Hubert was an invited speaker at the <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">American Society of Toxicology (SOT) 2025<\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\"> meeting in March presenting Peppers work on readiness of methods for validation, a work that is anchored in the ReadEDtest tool. <\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-143\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b143\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"143\" id=\"section_b6d0dbec536d28b2fee43250bfe96687\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--25\" data-block-id=\"-25\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" align=\"center\" id=\"b-14\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-14\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--31\" data-block-id=\"-31\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" id=\"b148\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"148\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover;padding-top:0px;padding-bottom:0px\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" style=\"table-layout:fixed\" role=\"presentation\"><colgroup><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><\/colgroup><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId-145\" data-block-id=\"145\" colspan=\"5\" width=\"41.66666666666667%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b149\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"85%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:85%;width:85%;height:auto\" role=\"presentation\" data-testid=\"image-149\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/dim.mcusercontent.com\/cs\/679c707fab1e7bd2bc8364edc\/images\/1e19e6ff-dea0-629c-bbc4-907de4c82f74.png?dpr=2&rect=0%2C0%2C883%2C800&w=206&h=186\" width=\"206.54999999999998\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"149\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId-147\" data-block-id=\"147\" colspan=\"7\" width=\"58.333333333333336%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b150\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"85%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:85%;width:85%;height:auto\" role=\"presentation\" data-testid=\"image-150\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/dim.mcusercontent.com\/cs\/679c707fab1e7bd2bc8364edc\/images\/0ce60fd3-11df-2ba5-e450-d4f5ad9e338e.png?dpr=2&rect=0%2C68%2C970%2C550&w=353&h=200\" width=\"300.05\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"150\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-131\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b131\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"131\" class=\"mceText\" id=\"d131\" style=\"width:100%\"><h4 style=\"text-align: left;\"><span style=\"font-family: 'DM Sans', sans-serif\">AFARA conference<\/span><\/h4><h4 style=\"text-align: left;\"><\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Peppers CSO Torben \u00d6sterlund was an invited speaker at the <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">Dutch consortium for reducing animal studies (AFARA) <\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\">talking about the validation process and strategy at Pepper. He also gave a similar lecture at <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">the UNIgreen\/SupBiotech cell biology summer school<\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\"> (Biotechnological advances in monitoring of pollutions in the environment) in Paris in July.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b159\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"45%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:45%;width:45%;height:auto\" role=\"presentation\" data-testid=\"image-159\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/5408b071-d6c4-3785-7eb6-5785cafa47d4.png\" width=\"275.40000000000003\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"159\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-132\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b132\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"132\" class=\"mceText\" id=\"d132\" style=\"width:100%\"><h4 style=\"text-align: left;\"><span style=\"font-family: 'DM Sans', sans-serif\">Eurotox 2025 <\/span><\/h4><h4 style=\"text-align: left;\"><\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">In September Torben attended the <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">Eurotox 2025<\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\"> conference in Athens, Greece. This was a fine opportunity to meet with many of our friends and collaborators as well as other key stakeholders. Torben presented a poster on our latest successful validation study and discussed several new methods that are relevant for validation.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-151\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b151\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"151\" id=\"section_19c022bb8e5bfd90eafec9ad8e663d53\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--26\" data-block-id=\"-26\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" align=\"center\" id=\"b-16\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-16\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--32\" data-block-id=\"-32\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" id=\"b156\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"156\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover;padding-top:0px;padding-bottom:0px\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" style=\"table-layout:fixed\" role=\"presentation\"><colgroup><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><\/colgroup><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"center\" class=\"mceColumn\" id=\"mceColumnId-153\" data-block-id=\"153\" colspan=\"3\" width=\"25%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b157\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-157\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/052b3917-9311-c5be-4552-225e30cad473.png\" width=\"133\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"157\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><td style=\"padding-top:0;padding-bottom:0\" valign=\"center\" class=\"mceColumn\" id=\"mceColumnId-155\" data-block-id=\"155\" colspan=\"9\" width=\"75%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b158\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-158\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/4a501a6b-883f-b396-a386-8bec3899b418.jpg\" width=\"463\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"158\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-133\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b133\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"133\" class=\"mceText\" id=\"d133\" style=\"width:100%\"><h4 style=\"text-align: left;\"><span style=\"font-family: 'DM Sans', sans-serif\">Akademie Fresenius Conference Endocrine Disruptors \u00a0<\/span><\/h4><h4 style=\"text-align: left;\"><\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Lastly, in November Torben was an invited speaker at the <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">Akademie Fresenius Conference <\/span><\/strong><em><strong><span style=\"font-family: 'DM Sans', sans-serif\">Endocrine Disruptors<\/span><\/strong><\/em><strong><span style=\"font-family: 'DM Sans', sans-serif\"> in Dusseldorf<\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\">, Germany. Here he presented the Pepper strategy for assessing method readiness, the validation project process, and the test guideline process with OECD. This meeting was focused on EDs and the methods to discover these, a core part of Peppers\u2019 business.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-160\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b160\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"160\" id=\"section_889018aba7969c2801ae43d038ce2d94\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--27\" data-block-id=\"-27\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" align=\"center\" id=\"b-18\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-18\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--33\" data-block-id=\"-33\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" id=\"b165\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"165\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover;padding-top:0px;padding-bottom:0px\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" style=\"table-layout:fixed\" role=\"presentation\"><colgroup><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><\/colgroup><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"center\" class=\"mceColumn\" id=\"mceColumnId-162\" data-block-id=\"162\" colspan=\"4\" width=\"33.33333333333333%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b161\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-161\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/03b408f7-5132-15f9-7d23-cbf6aa350e44.jpeg\" width=\"188\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"161\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><td style=\"padding-top:0;padding-bottom:0\" valign=\"center\" class=\"mceColumn\" id=\"mceColumnId-164\" data-block-id=\"164\" colspan=\"8\" width=\"66.66666666666666%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b163\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-163\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/3c0aa855-5e2e-748a-0928-07c63482cc42.png\" width=\"408\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"163\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-134\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b134\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"134\" class=\"mceText\" id=\"d134\" style=\"width:100%\"><h4 style=\"text-align: left;\"><span style=\"font-family: 'DM Sans', sans-serif\">Miscellaneous <\/span><\/h4><h4 style=\"text-align: left;\"><\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Apart from the conferences and symposia, Pepper is also actively involved in several initiatives on method validation in Europe including: The EU roadmap for phasing out animal use in research, the European Test Method & Validation Strategy, the pan European consortium NAMWISE, the OECD guidance document 34 updating, and the OECD Expert Group on steroidogenesis. In particular the NAMWISE project is key to Pepper since this consortium works on the NAM enhancement and Pepper is involved in two key work packages on NAM readiness and case stories, as well as the business model of validation.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:20px;padding-bottom:20px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceDividerBlockContainer\" id=\"b50\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"background-color:transparent;width:100%\" role=\"presentation\" class=\"mceDividerContainer\" data-block-id=\"50\"><tbody><tr><td style=\"min-width:100%;border-top-width:2px;border-top-style:dotted;border-top-color:#d3e2ff;line-height:0;font-size:0\" valign=\"top\" class=\"mceDividerBlock\">\u00a0<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-111\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b111\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"111\" class=\"mceText\" id=\"d111\" style=\"width:100%\"><p><br><\/p><h1 class=\"mcePastedContent last-child\">The Pepper pipeline<\/h1><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-34\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b34\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:24px\" class=\"mceTextBlockContainer\"><div data-block-id=\"34\" class=\"mceText\" id=\"d34\" style=\"width:100%\"><p><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">This summer we announced the <\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-family: 'DM Sans', sans-serif\">submission of the second validation report to OECD<\/span><\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\"> following a successful validation study and the report is currently undergoing peer review. We have since finalized a scientific article about the project and submitted for publication. This covers the Retinoic acid receptor transactivation assay out of INSERM\/University of Montpellier. With this, <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">Pepper have finalized four validation studies of which two have proceeded for review and test guideline drafting with OCED.<\/span><\/strong><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b112\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"37%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:37%;width:37%;height:auto\" role=\"presentation\" data-testid=\"image-112\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/0d2e332a-82c3-7232-29ca-e669dc246d44.jpg\" width=\"244.2\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"112\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-135\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b135\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:24px\" class=\"mceTextBlockContainer\"><div data-block-id=\"135\" class=\"mceText\" id=\"d135\" style=\"width:100%\"><p><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Pepper has a further <\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-family: 'DM Sans', sans-serif\">9 ongoing projects <\/span><\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\">at different stages of validation, from an update of the TG456 on steroidogenesis since 2020, to the latest two projects just initiated this year. The project pipeline cover key methods in the ED space expanding the number of steroid receptor assays and other nuclear receptor transcription factor based assays, that all influence a wealth of important cell biology and have multiple adverse outcomes when disrupted. Another key area is the thyroid hormone regulation which can be addressed at many levels and for which we currently have two interesting projects. Pepper also have two projects in the developmental neuro-toxicity space that seek to determine adverse effects on neuronal development, an area that is of increasing interest in the ED space, since even subtle molecular effects can be of importance for the brain development of the embryo. These two methods belong the phenotypic types of assays that cover several cellular mechanisms.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:20px;padding-bottom:20px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceDividerBlockContainer\" id=\"b53\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"background-color:transparent;width:100%\" role=\"presentation\" class=\"mceDividerContainer\" data-block-id=\"53\"><tbody><tr><td style=\"min-width:100%;border-top-width:2px;border-top-style:dotted;border-top-color:#d3e2ff;line-height:0;font-size:0\" valign=\"top\" class=\"mceDividerBlock\">\u00a0<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-29\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b29\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:5px\" class=\"mceTextBlockContainer\"><div data-block-id=\"29\" class=\"mceText\" id=\"d29\" style=\"width:100%\"><h1 style=\"text-align: left;\"><strong>The Pepper business<\/strong><\/h1><p style=\"text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h4 style=\"text-align: left;\">Strengthening the Pepper Model<\/h4><h4 style=\"text-align: left;\"><\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Since its initiation in 2019 Pepper has had the business model of sponsoring validation studies by economically supporting participating laboratories and other key players that covers different aspects of each project. We engage a data manager and a statistician in each project to gather and analyze the submitted data, we seek advice from experts and our scientific council,\u00a0 and we engage with the OECD for optimal interactions and progress. The economic support comes from our founding members and other supporting partners that are keen to support validation of methods. These are French ministries, industrial partners, and organizations that early on wanted to see acceleration of method validation, a key bottleneck for the regulatory transition. <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">We are now reaching out to more potential partners showcasing our success to attract further funding and potentially expanding our activities beyond the ED methods and to generally support NAM validation. If you and your organization are interested in supporting the Pepper mission, please reach out and we can have a discussion on this key topic.<\/span><\/strong><br><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b167\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"71%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:71%;width:71%;height:auto\" role=\"presentation\" data-testid=\"image-167\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/b589a62c-a219-1805-54af-a8db97ce1c84.png\" width=\"434.52\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"167\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-166\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b166\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:5px\" class=\"mceTextBlockContainer\"><div data-block-id=\"166\" class=\"mceText\" id=\"d166\" style=\"width:100%\"><h4>New service offer: training in validation<\/h4><p class=\"\" style=\"text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: "DM Sans", sans-serif\">Based on our increasing experience with method validation <\/span><strong><span style=\"font-family: "DM Sans", sans-serif\">we also offer on-site and online courses in validation project leadership. We strongly believe that this is a new professional profession that requires specific experiences and skills, which we can transfer to others that enter this business area.<\/span><\/strong><span style=\"font-family: "DM Sans", sans-serif\"> Our first course was for Dr. Sophie Rigal from BfR in March with whom we now collaborate in specific projects. We are also able to teach or assist in the process following the laboratory work of validation, regarding submissions and reviews under OECD. We are experienced with Validation report writing and submission, the peer review process, the follow up on this, and the test guideline drafting and review. This is also an area where we can offer to assist and teach based on these experiences.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:20px;padding-bottom:20px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceDividerBlockContainer\" id=\"b136\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"background-color:transparent;width:100%\" role=\"presentation\" class=\"mceDividerContainer\" data-block-id=\"136\"><tbody><tr><td style=\"min-width:100%;border-top-width:2px;border-top-style:dotted;border-top-color:#d3e2ff;line-height:0;font-size:0\" valign=\"top\" class=\"mceDividerBlock\">\u00a0<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-137\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b137\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:5px\" class=\"mceTextBlockContainer\"><div data-block-id=\"137\" class=\"mceText\" id=\"d137\" style=\"width:100%\"><h1 style=\"text-align: left;\"><strong>A look toward 2026<\/strong><\/h1><p style=\"text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h4 style=\"text-align: left;\">New methods<\/h4><p class=\"\" style=\"text-align: left;\"><br><\/p><p><span style=\"font-family: 'DM Sans', sans-serif\">Pepper is gearing up to initiate validation of new methods that were on the top our new priority list following the annual meeting of the Relevance Committee in November. One will be initiated immediately and one later on when Andrea is back in action. We are also expecting to finish a couple of projects in 2026, write a validation report for each and submit for review under OECD. This should hopefully also lead to writing and submission of two more scientific articles covering these projects.<\/span><\/p><p class=\"\" style=\"text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h4 style=\"text-align: left;\">Future event<\/h4><p class=\"\" style=\"text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">For Pepper the next <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">ESTIV <\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\">(European Society of Toxicology <\/span><em><span style=\"font-family: 'DM Sans', sans-serif\">In Vitro<\/span><\/em><span style=\"font-family: 'DM Sans', sans-serif\">) congress (29 June- 2 July 2026, Maastricht) will be of key importance. This meeting is in Maastricht (NL) and is called: <\/span><em><span style=\"font-family: 'DM Sans', sans-serif\">Ensuring Safety, Advancing Science: Bridging to the Future with NAMs<\/span><\/em><span style=\"font-family: 'DM Sans', sans-serif\">. This aligns perfectly with the mission of Pepper to accelerate validation of NAMs in the ED space and with the scope of NAMWISE we are participating in. This will also be the best option to interact with many of our collaborators and friends from around Europe. If you are at the ESTIV meeting in June\/July please reach out to us for a meeting over coffee or seek us at our booth. We will update more on this during the spring on LinkedIn and at our homepage.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b141\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"85%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:85%;width:85%;height:auto\" role=\"presentation\" data-testid=\"image-141\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/0bb155ac-c12d-7d62-e6ad-4d8a1577a64c.png\" width=\"520.1999999999999\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"141\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:20px;padding-bottom:20px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceDividerBlockContainer\" id=\"b138\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"background-color:transparent;width:100%\" role=\"presentation\" class=\"mceDividerContainer\" data-block-id=\"138\"><tbody><tr><td style=\"min-width:100%;border-top-width:2px;border-top-style:dotted;border-top-color:#d3e2ff;line-height:0;font-size:0\" valign=\"top\" class=\"mceDividerBlock\">\u00a0<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-139\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b139\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:5px\" class=\"mceTextBlockContainer\"><div data-block-id=\"139\" class=\"mceText\" id=\"d139\" style=\"width:100%\"><h1 style=\"text-align: justify;\"><strong>NAMWISE updates<\/strong><\/h1><p><br><\/p><p><br><\/p><p><span style=\"font-family: 'DM Sans', sans-serif\">This year was marked by the first in motion actions of the NAMWISE project Pepper is part of. \u00a0Pepper contributes to NAMWISE by leveraging its expertise in the validation of bioassays relevant to regulatory frameworks. As a public-private platform, Pepper helps bridge the gap between academic innovation and regulatory needs by selecting promising methods, ensuring reproducibility and transferability, and supporting their transition into internationally recognized guidelines such as those of the OECD.<\/span><\/p><p><span style=\"font-family: 'DM Sans', sans-serif\">To learn more about the project you can visit the website: <\/span><a href=\"http:\/\/www.namwise.eu\"><span style=\"font-family: 'DM Sans', sans-serif\">www.namwise.eu<\/span><\/a><\/p><p><br><\/p><p><span style=\"font-family: 'DM Sans', sans-serif\">You can also discover how NAMWISE mapped and analysed training resources on New Approach Methodologies (NAMs) across Europe: identifying key initiatives, audiences, and gaps to strengthen future education and capacity building >> <\/span><a href=\"https:\/\/namwise.eu\/content\/uploads\/2025\/10\/NAMWISE_Deliverable_D2.6_Mapping-of-training.pdf\" target=\"_blank\"><span style=\"font-family: 'DM Sans', sans-serif\">here<\/span><\/a><\/p><p class=\"mcePastedContent last-child\"><br><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b140\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"85%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:85%;width:85%;height:auto\" role=\"presentation\" data-testid=\"image-140\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/a7abb4d8-6d93-fa25-13e4-e8ba166bf75f.png\" width=\"520.1999999999999\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"140\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-71\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"background-color:#00a1d8;padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b71\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"71\" id=\"section_b73c27320b01ebbc6421f7ee5eb2f4ec\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" 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All rights reserved.<\/span><\/em><span style=\"font-size: 12px\"><br>Nous vous envoyons cet e-mail, car vous vous \u00eates abonn\u00e9 via notre site Web.<br><br>Our mailing address is:<br>PEPPER\n22 Rue Charcot\nParis 75013\nFrance<br><br>Want to change how you receive these emails?<\/span><\/p><p class=\"last-child\"><span style=\"font-size: 12px\">You can <\/span><a href=\"https:\/\/ed-pepper.us2.list-manage.com\/profile?u=679c707fab1e7bd2bc8364edc&id=9bcab06e8f&e=[UNIQID]&c=6077818695\"><span style=\"font-size: 12px\">update your preferences<\/span><\/a><span style=\"font-size: 12px\"> or <\/span><a href=\"https:\/\/ed-pepper.us2.list-manage.com\/unsubscribe?u=679c707fab1e7bd2bc8364edc&id=9bcab06e8f&t=b&e=[UNIQID]&c=6077818695\"><span style=\"font-size: 12px\">unsubscribe<\/span><\/a><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" align=\"center\" id=\"b-2\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-2\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover;padding-top:0px;padding-bottom:0px\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" role=\"presentation\"><tbody><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table>\n<\/td>\n<\/tr>\n<\/tbody><\/table>\n<\/center>\n<\/body><\/html>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud835\udde7\ud835\uddf5\ud835\uddf2 December 2025 \ud835\uddf2\ud835\uddf1\ud835\uddf6\ud835\ude01\ud835\uddf6\ud835\uddfc\ud835\uddfb \ud835\uddfc\ud835\uddf3 \ud835\udde1\ud835\uddf2\ud835\ude04\ud835\ude00\ud835\udde3\ud835\uddf2\ud835\uddfd\ud835\uddfd\ud835\uddf2\ud835\uddff \ud835\uddf6\ud835\ude00 \ud835\uddfb\ud835\uddfc\ud835\ude04 \ud835\uddf9\ud835\uddf6\ud835\ude03\ud835\uddf2! Dive into the latest on endocrine disruption, regulation, method validation, and Pepper\u2019s journey bridging research and regulatory impact. \ud83d\udd0d What\u2019s inside this issue:\ud83d\udea8 Policy spotlights\ud83d\udcc5 Events recap & upcoming\ud83e\uddea Pepper news \ud835\udde5\ud835\uddf2\ud835\uddee\ud835\uddf1 \ud835\ude01\ud835\uddf5\ud835\uddf2 \ud835\uddf3\ud835\ude02\ud835\uddf9\ud835\uddf9 \ud835\uddfb\ud835\uddf2\ud835\ude04\ud835\ude00\ud835\uddf9\ud835\uddf2\ud835\ude01\ud835\ude01\ud835\uddf2\ud835\uddff \ud835\uddf5\ud835\uddf2\ud835\uddff\ud835\uddf2: https:\/\/mailchi.mp\/ed-pepper\/newspepper_dec25-6254225Don\u2019t miss the next one, register NOW: https:\/\/lnkd.in\/eBDMhNWd NewsPepper: the […]<\/p>\n","protected":false},"author":5,"featured_media":8017,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52,51],"tags":[],"class_list":["post-8023","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newsletter","category-pepper-en"],"_links":{"self":[{"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/posts\/8023","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/comments?post=8023"}],"version-history":[{"count":2,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/posts\/8023\/revisions"}],"predecessor-version":[{"id":8025,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/posts\/8023\/revisions\/8025"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/media\/8017"}],"wp:attachment":[{"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/media?parent=8023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/categories?post=8023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/tags?post=8023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

{"id":8023,"date":"2026-01-14T10:26:01","date_gmt":"2026-01-14T09:26:01","guid":{"rendered":"https:\/\/ed-pepper.eu\/?p=8023"},"modified":"2026-01-14T10:26:03","modified_gmt":"2026-01-14T09:26:03","slug":"december-25-newspepper","status":"publish","type":"post","link":"https:\/\/ed-pepper.eu\/en\/december-25-newspepper\/","title":{"rendered":"December 25 NewsPepper"},"content":{"rendered":"\n

\ud835\udde7\ud835\uddf5\ud835\uddf2 December 2025 \ud835\uddf2\ud835\uddf1\ud835\uddf6\ud835\ude01\ud835\uddf6\ud835\uddfc\ud835\uddfb \ud835\uddfc\ud835\uddf3 \ud835\udde1\ud835\uddf2\ud835\ude04\ud835\ude00\ud835\udde3\ud835\uddf2\ud835\uddfd\ud835\uddfd\ud835\uddf2\ud835\uddff \ud835\uddf6\ud835\ude00 \ud835\uddfb\ud835\uddfc\ud835\ude04 \ud835\uddf9\ud835\uddf6\ud835\ude03\ud835\uddf2!

Dive into the latest on endocrine disruption, regulation, method validation, and Pepper\u2019s journey bridging research and regulatory impact.

\ud83d\udd0d What\u2019s inside this issue:
\ud83d\udea8 Policy spotlights
\ud83d\udcc5 Events recap & upcoming
\ud83e\uddea Pepper news

\ud835\udde5\ud835\uddf2\ud835\uddee\ud835\uddf1 \ud835\ude01\ud835\uddf5\ud835\uddf2 \ud835\uddf3\ud835\ude02\ud835\uddf9\ud835\uddf9 \ud835\uddfb\ud835\uddf2\ud835\ude04\ud835\ude00\ud835\uddf9\ud835\uddf2\ud835\ude01\ud835\ude01\ud835\uddf2\ud835\uddff \ud835\uddf5\ud835\uddf2\ud835\uddff\ud835\uddf2: https:\/\/mailchi.mp\/ed-pepper\/newspepper_dec25-6254225<\/a>
Don\u2019t miss the next one, register NOW: https:\/\/lnkd.in\/eBDMhNWd<\/a><\/p>\n\n\n\n\n\n\n\n\nNewsPepper: the newsletter of the public-private platform for the validation of endocrine disruptors characterization methods<\/title>\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.gstatic.com\" crossorigin=\"\">\n<link rel=\"stylesheet\" type=\"text\/css\" id=\"newGoogleFontsStatic\" href=\"https:\/\/fonts.googleapis.com\/css?family=DM+Sans:400,400i,700,700i,900,900i|Playfair+Display:400,400i,700,700i,900,900i\"><style>img{-ms-interpolation-mode:bicubic;}\ntable, td{mso-table-lspace:0pt;mso-table-rspace:0pt;}\n.mceStandardButton, .mceStandardButton td, .mceStandardButton td a{mso-hide:all!important;}\np, a, li, td, blockquote{mso-line-height-rule:exactly;}\np, a, li, td, body, table, blockquote{-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;}\n.mcnPreviewText{display:none!important;}\n.bodyCell{margin:0 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max-width:0px; opacity:0; overflow:hidden; visibility:hidden; mso-hide:all;\">December 2025<\/span>\n\n<div style=\"display: none; max-height: 0px; overflow: hidden;\">\u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c 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\u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c 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\u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007 \u034f \u200c \u00a0 \u2007\u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad \u00ad<\/div>\n<center>\n<table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" height=\"100%\" width=\"100%\" id=\"bodyTable\" style=\"background-color: rgb(0, 161, 216);\">\n<tbody><tr>\n<td class=\"bodyCell\" align=\"center\" valign=\"top\">\n<table id=\"root\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\"><tbody data-block-id=\"4\" class=\"mceWrapper\"><tr><td style=\"background-color:transparent\" valign=\"top\" align=\"center\" class=\"mceSectionHeader\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"max-width:660px\" role=\"presentation\"><tbody><tr><td style=\"background-color:#ffffff\" valign=\"top\" class=\"mceWrapperInner\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"3\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--19\" data-block-id=\"-19\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"left\" id=\"b6\"><div><\/div><a href=\"https:\/\/ed-pepper.eu\" style=\"display:block\" target=\"_blank\" data-block-id=\"6\"><table align=\"left\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-6\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/a390623f-8eeb-fdf8-d1e2-bf46027f52ef.jpg\" width=\"660\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\"><\/td><\/tr><\/tbody><\/table><\/a><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><tbody data-block-id=\"19\" class=\"mceWrapper\"><tr><td style=\"background-color:transparent\" valign=\"top\" align=\"center\" class=\"mceSectionBody\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"max-width:660px\" role=\"presentation\"><tbody><tr><td style=\"background-color:#ffffff\" valign=\"top\" class=\"mceWrapperInner\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"18\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--20\" data-block-id=\"-20\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-123\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b123\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"123\" id=\"section_f971925c7622f25499212939661a9fb5\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--24\" data-block-id=\"-24\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" align=\"center\" id=\"b-12\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-12\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--30\" data-block-id=\"-30\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" id=\"b128\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"128\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover;padding-top:0px;padding-bottom:0px\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" style=\"table-layout:fixed\" role=\"presentation\"><colgroup><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><\/colgroup><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId-125\" data-block-id=\"125\" colspan=\"8\" width=\"66.66666666666666%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-122\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b122\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"122\" class=\"mceText\" id=\"d122\" style=\"width:100%\"><h2><\/h2><h2 class=\"last-child\"><span style=\"font-size: 15px\"><span style=\"font-family: 'DM Sans', sans-serif\">Welcome the 4th\u00a0newsletter (NewsPepper) from Pepper in 2025. We provide updates on our activities and general important issues in the world of Endocrine Disruption sciences. <\/span><\/span><\/h2><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId-127\" data-block-id=\"127\" colspan=\"4\" width=\"33.33333333333333%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-87\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b87\"><table width=\"100%\" style=\"border:0;background-color:#f5f7f9;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"87\" class=\"mceText\" id=\"d87\" style=\"width:100%\"><p><strong><span style=\"color:#222328;\"><span style=\"font-size: 12px\">Summary<\/span><\/span><\/strong><\/p><p><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 1. Recap 2025<\/span><\/span><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%;\"><br><\/p><p class=\"mcePastedContent\"><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 2. Policy news<\/span><\/span><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%;\"><br><\/p><p class=\"mcePastedContent\"><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 3. Scientific conferences and consortia<br> \u00a0 \u00a04. The Pepper pipeline<\/span><\/span><\/p><p class=\"mcePastedContent\"><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 \u00a05. The Pepper business<\/span><\/span><\/p><p class=\"mcePastedContent\"><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 \u00a06. A look toward 2026<\/span><\/span><\/p><p class=\"mcePastedContent last-child\"><span style=\"color:#222328;\"><span style=\"font-size: 12px\"> \u00a0 \u00a07. Namwise updates<\/span><\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-44\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b44\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"44\" id=\"section_7b6f2a520fb7b5b4387ba3b558ec9efa\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--22\" data-block-id=\"-22\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" align=\"center\" id=\"b-8\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-8\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--28\" data-block-id=\"-28\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" id=\"b49\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"49\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId-46\" data-block-id=\"46\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-27\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b27\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"27\" class=\"mceText\" id=\"d27\" style=\"width:100%\"><h1 class=\"last-child\">Recap 2025<\/h1><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-88\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b88\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"88\" class=\"mceText\" id=\"d88\" style=\"width:100%\"><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">The year 2025 has in many ways been extraordinary for Pepper. This was the year with real breakthroughs with respect to method validation and dissemination. We have submitted <\/span><\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-size: 16px\"><span style=\"font-family: 'DM Sans', sans-serif\">the first draft test guideline<\/span><\/span><\/span><\/strong><span style=\"color:#00a1d8;\"><span style=\"font-size: 16px\"><span style=\"font-family: 'DM Sans', sans-serif\"> <\/span><\/span><\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-size: 16px\"><span style=\"font-family: 'DM Sans', sans-serif\">to OECD<\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\"> <\/span><\/span><\/strong><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">and <\/span><\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-size: 16px\"><span style=\"font-family: 'DM Sans', sans-serif\">published the first scientific article covering this successful validation project<\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">.<\/span><\/span><\/strong><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\"> The second method validation report was submitted for peer review under OECD and a manuscript for this project was also submitted for publication. The Pepper pipeline is maturing significantly at the moment, and we foresee more submissions in 2026 to both OECD and scientific journals.<\/span><\/span><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00a0<\/span><\/span><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">It was also the year when we said goodbye to our founding Director Philippe Hubert that was the locomotive in establishing Pepper and its supporting committees. Philippe could retire with the knowledge that Pepper has evolved into an international (4 countries are represented in the team) professional method validation unit with contacts and support throughout the European community of Endocrine Disruption research and beyond. We also welcomed and had to say goodbye to Celine Boudet as Director, coming from INERIS (L’Institut national de l’environnement industriel et des risques, FR) with a wealth of experience in environmental toxicology and large research projects, Celine was also involved when Pepper was initiated six years ago out of an INERIS project. Celine made a big impact on the new business model for Pepper and managed to influence the organization in a comprehensive way. However, she decided to go back to INERIS where she has worked for many years close to research with environmental impact.<\/span><\/span><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00a0<\/span><\/span><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">A key new step for Pepper was the <\/span><\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-size: 16px\"><span style=\"font-family: 'DM Sans', sans-serif\">signing of a formal collaboration agreement with BfR<\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\"> <\/span><\/span><\/strong><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">(The German Federal Institute for Risk Assessment) the German counterpart of INERIS. In this agreement we support each other on specific validation projects and share experiences, while BfR builds a validation effort themselves. We already collaborate in specific projects and have regular exchanges of ideas and information.<\/span><\/span><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00a0<\/span><\/span><\/p><p class=\"\" style=\"text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">Lastly, 2025 was the year when a Pepper team member became a parent for the first time. On Tuesday the 14<\/span><\/span><sup><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">th<\/span><\/span><\/sup><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\"> of October Andrea gave birth to a healthy baby girl and the whole team congratulates her and the family. Andrea will return to action at Pepper in 2026.<\/span><\/span><\/p><p style=\"text-align: left;\" class=\"last-child\"><br><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b142\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-142\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/b71fc02d-e36e-6a59-a255-72d77ba51169.png\" width=\"628\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"142\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-129\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b129\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"129\" class=\"mceText\" id=\"d129\" style=\"width:100%\"><h1 class=\"last-child\">Policy News<\/h1><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-130\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b130\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"130\" class=\"mceText\" id=\"d130\" style=\"width:100%\"><h4 style=\"text-align: left;\">EU provisional agreement to update water-pollutant priority lists: PFAS, bisphenols, pesticides included<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">On 23 September 2025, Council of the EU and European Parliament reached a provisional deal to revise the list of \u201cpriority pollutants\u201d for surface- and groundwater. The updated list adds PFAS (including TFA), certain bisphenols, pesticides, pharmaceuticals and more. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">This revision strengthens environmental-quality standards, updates norms, and aims to align regulation with latest scientific evidence. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">Member States will have until 2039 (or under certain conditions until 2045) to comply fully; for some substances, deadlines may be earlier (e.g. 2033) depending on new standards. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h4 style=\"text-align: left;\">European Chemicals Agency (ECHA) advances PFAS restrictions under REACH & call from endocrine-health societies<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: Symbol\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: "Times New Roman"\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/span><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\"> <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">In October 2025, ECHA announced that its \u201cSocio-Economic Analysis Committee\u201d (SEAC) would issue its draft opinion on the revised PFAS restriction proposal \u2014 a necessary step before final ban decisions. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">On October 30, key medical bodies \u2014 European Society of Endocrinology (ESE), European Society for Paediatric Endocrinology (ESPE), and Endocrine Society \u2014 jointly urged regulators to adopt a universal PFAS restriction, emphasizing health risks and the need to phase out PFAS where safer alternatives exist.<\/span><\/span><\/p><p style=\"text-align: left;\"><strong> \u00a0<\/strong><\/p><h4 style=\"text-align: left;\">Evidence PFAS exposure may cause endocrine disruption in women<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: Symbol\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: "Times New Roman"\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0<\/span><\/span><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">A recent study (Dec 2025) <\/span><\/span><span style=\"font-size: 10.5pt\"><span style=\"font-family: 'DM Sans', sans-serif\">published the \u00a0medical journal \u00a0JAMA Network Open<\/span><\/span><span style=\"color:rgb(26, 27, 27);\"><span style=\"font-size: 10.5pt\"><span style=\"font-family: 'DM Sans', sans-serif\"> <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">found that high PFAS exposure in women is associated with altered hormone profiles \u2014 reinforcing concerns about PFAS as endocrine disruptors.<\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">This strengthens calls from health & endocrine societies for stricter regulation and accelerated removal of PFAS from consumer products and the environment. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%;\"><br><\/p><h4 class=\"mcePastedContent\" style=\"text-align: left;\">ANSES confirms widespread PFAS in French tap water<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%;\"><br><\/p><p class=\"mcePastedContent\" style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">A major nationwide study (2023\u20132025) by ANSES found that 92 % of tap-water samples tested positive for a PFAS breakdown product, trifluoroacetic acid (TFA). <\/span><\/span><\/p><p class=\"mcePastedContent\" style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">Beyond the 20 PFAS covered by the EU drinking-water directive, the agency also detected other PFAS and calls for a broader monitoring scheme. <\/span><\/span><\/p><p class=\"mcePastedContent\" style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">The findings are a wake-up call for regulators: many PFAS remain unmonitored despite pervasive presence. <\/span><\/span><\/p><p><br><\/p><h4 style=\"text-align: left;\">European Chemicals Agency (ECHA) & Organisation for Economic Co-operation and Development (OECD) \u2014 Update of QSAR Toolbox and support for non-animal hazard assessment methods<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: Symbol\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: "Times New Roman"\"><span style=\"font-weight:normal;\">\u00a0\u00a0<\/span><\/span><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">On 8 October 2025, a new version of the OECD QSAR Toolbox (4.8) was released. The update includes enhancements to structural data import, metabolism databases, and improved transparency and security. <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">The upgraded toolbox supports computational predictions of chemical hazards, which can help avoid or reduce animal testing \u2014 aligning with ambitions of non-animal methods for endocrine disruptor (ED) assessment.<\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h4 style=\"text-align: left;\">Sant\u00e9 publique France \u2014 New national health-surveillance program on exposures and effects of endocrine disruptors<\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\"><span style=\"font-size: 10pt\"><span style=\"font-family: Symbol\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: "Times New Roman"\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">On 7 November 2025, Sant\u00e9 publique France published a design for a health-surveillance program focused on the health effects of exposure to endocrine disruptors (EDs). The program prioritizes certain health outcomes (e.g. neurodevelopmental disorders in children, metabolic issues, reproductive health). <\/span><\/span><\/p><p style=\"margin-left: 36.0pt; text-indent: -18.0pt; mso-list: l0 level1 lfo1; tab-stops: list 36.0pt; text-align: left;\" class=\"last-child\"><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">\u00b7<\/span><\/span><span style=\"font-size: 7pt\"><span style=\"font-family: 'DM Sans', sans-serif\"><span style=\"font-weight:normal;\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/span><\/span><span style=\"font-size: 10pt\"><span style=\"font-family: 'DM Sans', sans-serif\">This marks a stepping stone toward what may feed into the upcoming second National Strategy on Endocrine Disruptors (Strat\u00e9gie nationale sur les perturbateurs endocriniens \u2013 SNPE2), reinforcing monitoring at population level. <\/span><\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:20px;padding-bottom:20px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceDividerBlockContainer\" id=\"b36\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"background-color:transparent;width:100%\" role=\"presentation\" class=\"mceDividerContainer\" data-block-id=\"36\"><tbody><tr><td style=\"min-width:100%;border-top-width:2px;border-top-style:dotted;border-top-color:#d3e2ff;line-height:0;font-size:0\" valign=\"top\" class=\"mceDividerBlock\">\u00a0<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-97\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b97\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"97\" class=\"mceText\" id=\"d97\" style=\"width:100%\"><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h1 style=\"text-align: left;\">Scientific conferences and consortia<\/h1><h1 style=\"text-align: left;\"><\/h1><h4 style=\"text-align: left;\"><span style=\"font-family: 'DM Sans', sans-serif\">American Society of Toxicology (SOT) 2025<\/span><\/h4><p style=\"text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Peppers is being recognized for its work in the validation of methods and bridging a significant gap in non-animal methods (NAMs) to bring these into the test guideline system and regulatory use. Director Philippe Hubert was an invited speaker at the <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">American Society of Toxicology (SOT) 2025<\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\"> meeting in March presenting Peppers work on readiness of methods for validation, a work that is anchored in the ReadEDtest tool. <\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-143\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b143\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"143\" id=\"section_b6d0dbec536d28b2fee43250bfe96687\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--25\" data-block-id=\"-25\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" align=\"center\" id=\"b-14\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-14\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--31\" data-block-id=\"-31\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" id=\"b148\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"148\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover;padding-top:0px;padding-bottom:0px\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" style=\"table-layout:fixed\" role=\"presentation\"><colgroup><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><\/colgroup><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId-145\" data-block-id=\"145\" colspan=\"5\" width=\"41.66666666666667%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b149\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"85%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:85%;width:85%;height:auto\" role=\"presentation\" data-testid=\"image-149\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/dim.mcusercontent.com\/cs\/679c707fab1e7bd2bc8364edc\/images\/1e19e6ff-dea0-629c-bbc4-907de4c82f74.png?dpr=2&rect=0%2C0%2C883%2C800&w=206&h=186\" width=\"206.54999999999998\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"149\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><td style=\"padding-top:0;padding-bottom:0\" valign=\"top\" class=\"mceColumn\" id=\"mceColumnId-147\" data-block-id=\"147\" colspan=\"7\" width=\"58.333333333333336%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b150\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"85%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:85%;width:85%;height:auto\" role=\"presentation\" data-testid=\"image-150\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/dim.mcusercontent.com\/cs\/679c707fab1e7bd2bc8364edc\/images\/0ce60fd3-11df-2ba5-e450-d4f5ad9e338e.png?dpr=2&rect=0%2C68%2C970%2C550&w=353&h=200\" width=\"300.05\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"150\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-131\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b131\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"131\" class=\"mceText\" id=\"d131\" style=\"width:100%\"><h4 style=\"text-align: left;\"><span style=\"font-family: 'DM Sans', sans-serif\">AFARA conference<\/span><\/h4><h4 style=\"text-align: left;\"><\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Peppers CSO Torben \u00d6sterlund was an invited speaker at the <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">Dutch consortium for reducing animal studies (AFARA) <\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\">talking about the validation process and strategy at Pepper. He also gave a similar lecture at <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">the UNIgreen\/SupBiotech cell biology summer school<\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\"> (Biotechnological advances in monitoring of pollutions in the environment) in Paris in July.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b159\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"45%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:45%;width:45%;height:auto\" role=\"presentation\" data-testid=\"image-159\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/5408b071-d6c4-3785-7eb6-5785cafa47d4.png\" width=\"275.40000000000003\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"159\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-132\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b132\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"132\" class=\"mceText\" id=\"d132\" style=\"width:100%\"><h4 style=\"text-align: left;\"><span style=\"font-family: 'DM Sans', sans-serif\">Eurotox 2025 <\/span><\/h4><h4 style=\"text-align: left;\"><\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">In September Torben attended the <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">Eurotox 2025<\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\"> conference in Athens, Greece. This was a fine opportunity to meet with many of our friends and collaborators as well as other key stakeholders. Torben presented a poster on our latest successful validation study and discussed several new methods that are relevant for validation.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-151\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b151\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"151\" id=\"section_19c022bb8e5bfd90eafec9ad8e663d53\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--26\" data-block-id=\"-26\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" align=\"center\" id=\"b-16\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-16\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--32\" data-block-id=\"-32\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" id=\"b156\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"156\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover;padding-top:0px;padding-bottom:0px\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" style=\"table-layout:fixed\" role=\"presentation\"><colgroup><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><\/colgroup><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"center\" class=\"mceColumn\" id=\"mceColumnId-153\" data-block-id=\"153\" colspan=\"3\" width=\"25%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b157\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-157\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/052b3917-9311-c5be-4552-225e30cad473.png\" width=\"133\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"157\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><td style=\"padding-top:0;padding-bottom:0\" valign=\"center\" class=\"mceColumn\" id=\"mceColumnId-155\" data-block-id=\"155\" colspan=\"9\" width=\"75%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b158\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-158\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/4a501a6b-883f-b396-a386-8bec3899b418.jpg\" width=\"463\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"158\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-133\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b133\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"133\" class=\"mceText\" id=\"d133\" style=\"width:100%\"><h4 style=\"text-align: left;\"><span style=\"font-family: 'DM Sans', sans-serif\">Akademie Fresenius Conference Endocrine Disruptors \u00a0<\/span><\/h4><h4 style=\"text-align: left;\"><\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Lastly, in November Torben was an invited speaker at the <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">Akademie Fresenius Conference <\/span><\/strong><em><strong><span style=\"font-family: 'DM Sans', sans-serif\">Endocrine Disruptors<\/span><\/strong><\/em><strong><span style=\"font-family: 'DM Sans', sans-serif\"> in Dusseldorf<\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\">, Germany. Here he presented the Pepper strategy for assessing method readiness, the validation project process, and the test guideline process with OECD. This meeting was focused on EDs and the methods to discover these, a core part of Peppers\u2019 business.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-160\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b160\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"160\" id=\"section_889018aba7969c2801ae43d038ce2d94\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--27\" data-block-id=\"-27\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" align=\"center\" id=\"b-18\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-18\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" id=\"mceColumnId--33\" data-block-id=\"-33\" colspan=\"12\" width=\"100%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"border:0;border-radius:0\" valign=\"top\" id=\"b165\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"165\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover;padding-top:0px;padding-bottom:0px\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" style=\"table-layout:fixed\" role=\"presentation\"><colgroup><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><col span=\"1\" width=\"8.333333333333332%\"><\/colgroup><tbody><tr><td style=\"padding-top:0;padding-bottom:0\" valign=\"center\" class=\"mceColumn\" id=\"mceColumnId-162\" data-block-id=\"162\" colspan=\"4\" width=\"33.33333333333333%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b161\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-161\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/03b408f7-5132-15f9-7d23-cbf6aa350e44.jpeg\" width=\"188\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"161\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><td style=\"padding-top:0;padding-bottom:0\" valign=\"center\" class=\"mceColumn\" id=\"mceColumnId-164\" data-block-id=\"164\" colspan=\"8\" width=\"66.66666666666666%\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:16px;padding-left:16px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b163\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:100%;width:100%;height:auto\" role=\"presentation\" data-testid=\"image-163\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/3c0aa855-5e2e-748a-0928-07c63482cc42.png\" width=\"408\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"163\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-134\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b134\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"134\" class=\"mceText\" id=\"d134\" style=\"width:100%\"><h4 style=\"text-align: left;\"><span style=\"font-family: 'DM Sans', sans-serif\">Miscellaneous <\/span><\/h4><h4 style=\"text-align: left;\"><\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Apart from the conferences and symposia, Pepper is also actively involved in several initiatives on method validation in Europe including: The EU roadmap for phasing out animal use in research, the European Test Method & Validation Strategy, the pan European consortium NAMWISE, the OECD guidance document 34 updating, and the OECD Expert Group on steroidogenesis. In particular the NAMWISE project is key to Pepper since this consortium works on the NAM enhancement and Pepper is involved in two key work packages on NAM readiness and case stories, as well as the business model of validation.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:20px;padding-bottom:20px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceDividerBlockContainer\" id=\"b50\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"background-color:transparent;width:100%\" role=\"presentation\" class=\"mceDividerContainer\" data-block-id=\"50\"><tbody><tr><td style=\"min-width:100%;border-top-width:2px;border-top-style:dotted;border-top-color:#d3e2ff;line-height:0;font-size:0\" valign=\"top\" class=\"mceDividerBlock\">\u00a0<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-111\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b111\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px\" class=\"mceTextBlockContainer\"><div data-block-id=\"111\" class=\"mceText\" id=\"d111\" style=\"width:100%\"><p><br><\/p><h1 class=\"mcePastedContent last-child\">The Pepper pipeline<\/h1><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-34\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b34\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:24px\" class=\"mceTextBlockContainer\"><div data-block-id=\"34\" class=\"mceText\" id=\"d34\" style=\"width:100%\"><p><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">This summer we announced the <\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-family: 'DM Sans', sans-serif\">submission of the second validation report to OECD<\/span><\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\"> following a successful validation study and the report is currently undergoing peer review. We have since finalized a scientific article about the project and submitted for publication. This covers the Retinoic acid receptor transactivation assay out of INSERM\/University of Montpellier. With this, <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">Pepper have finalized four validation studies of which two have proceeded for review and test guideline drafting with OCED.<\/span><\/strong><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b112\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"37%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:37%;width:37%;height:auto\" role=\"presentation\" data-testid=\"image-112\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/0d2e332a-82c3-7232-29ca-e669dc246d44.jpg\" width=\"244.2\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"112\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-135\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b135\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:24px\" class=\"mceTextBlockContainer\"><div data-block-id=\"135\" class=\"mceText\" id=\"d135\" style=\"width:100%\"><p><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Pepper has a further <\/span><strong><span style=\"color:#00a1d8;\"><span style=\"font-family: 'DM Sans', sans-serif\">9 ongoing projects <\/span><\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\">at different stages of validation, from an update of the TG456 on steroidogenesis since 2020, to the latest two projects just initiated this year. The project pipeline cover key methods in the ED space expanding the number of steroid receptor assays and other nuclear receptor transcription factor based assays, that all influence a wealth of important cell biology and have multiple adverse outcomes when disrupted. Another key area is the thyroid hormone regulation which can be addressed at many levels and for which we currently have two interesting projects. Pepper also have two projects in the developmental neuro-toxicity space that seek to determine adverse effects on neuronal development, an area that is of increasing interest in the ED space, since even subtle molecular effects can be of importance for the brain development of the embryo. These two methods belong the phenotypic types of assays that cover several cellular mechanisms.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:20px;padding-bottom:20px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceDividerBlockContainer\" id=\"b53\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"background-color:transparent;width:100%\" role=\"presentation\" class=\"mceDividerContainer\" data-block-id=\"53\"><tbody><tr><td style=\"min-width:100%;border-top-width:2px;border-top-style:dotted;border-top-color:#d3e2ff;line-height:0;font-size:0\" valign=\"top\" class=\"mceDividerBlock\">\u00a0<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-29\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b29\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:5px\" class=\"mceTextBlockContainer\"><div data-block-id=\"29\" class=\"mceText\" id=\"d29\" style=\"width:100%\"><h1 style=\"text-align: left;\"><strong>The Pepper business<\/strong><\/h1><p style=\"text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h4 style=\"text-align: left;\">Strengthening the Pepper Model<\/h4><h4 style=\"text-align: left;\"><\/h4><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">Since its initiation in 2019 Pepper has had the business model of sponsoring validation studies by economically supporting participating laboratories and other key players that covers different aspects of each project. We engage a data manager and a statistician in each project to gather and analyze the submitted data, we seek advice from experts and our scientific council,\u00a0 and we engage with the OECD for optimal interactions and progress. The economic support comes from our founding members and other supporting partners that are keen to support validation of methods. These are French ministries, industrial partners, and organizations that early on wanted to see acceleration of method validation, a key bottleneck for the regulatory transition. <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">We are now reaching out to more potential partners showcasing our success to attract further funding and potentially expanding our activities beyond the ED methods and to generally support NAM validation. If you and your organization are interested in supporting the Pepper mission, please reach out and we can have a discussion on this key topic.<\/span><\/strong><br><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b167\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"71%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:71%;width:71%;height:auto\" role=\"presentation\" data-testid=\"image-167\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/b589a62c-a219-1805-54af-a8db97ce1c84.png\" width=\"434.52\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"167\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-166\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b166\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:5px\" class=\"mceTextBlockContainer\"><div data-block-id=\"166\" class=\"mceText\" id=\"d166\" style=\"width:100%\"><h4>New service offer: training in validation<\/h4><p class=\"\" style=\"text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: "DM Sans", sans-serif\">Based on our increasing experience with method validation <\/span><strong><span style=\"font-family: "DM Sans", sans-serif\">we also offer on-site and online courses in validation project leadership. We strongly believe that this is a new professional profession that requires specific experiences and skills, which we can transfer to others that enter this business area.<\/span><\/strong><span style=\"font-family: "DM Sans", sans-serif\"> Our first course was for Dr. Sophie Rigal from BfR in March with whom we now collaborate in specific projects. We are also able to teach or assist in the process following the laboratory work of validation, regarding submissions and reviews under OECD. We are experienced with Validation report writing and submission, the peer review process, the follow up on this, and the test guideline drafting and review. This is also an area where we can offer to assist and teach based on these experiences.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:20px;padding-bottom:20px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceDividerBlockContainer\" id=\"b136\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"background-color:transparent;width:100%\" role=\"presentation\" class=\"mceDividerContainer\" data-block-id=\"136\"><tbody><tr><td style=\"min-width:100%;border-top-width:2px;border-top-style:dotted;border-top-color:#d3e2ff;line-height:0;font-size:0\" valign=\"top\" class=\"mceDividerBlock\">\u00a0<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-137\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b137\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:5px\" class=\"mceTextBlockContainer\"><div data-block-id=\"137\" class=\"mceText\" id=\"d137\" style=\"width:100%\"><h1 style=\"text-align: left;\"><strong>A look toward 2026<\/strong><\/h1><p style=\"text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h4 style=\"text-align: left;\">New methods<\/h4><p class=\"\" style=\"text-align: left;\"><br><\/p><p><span style=\"font-family: 'DM Sans', sans-serif\">Pepper is gearing up to initiate validation of new methods that were on the top our new priority list following the annual meeting of the Relevance Committee in November. One will be initiated immediately and one later on when Andrea is back in action. We are also expecting to finish a couple of projects in 2026, write a validation report for each and submit for review under OECD. This should hopefully also lead to writing and submission of two more scientific articles covering these projects.<\/span><\/p><p class=\"\" style=\"text-align: left;\"><br><\/p><p style=\"line-height: 0; mso-line-height-alt: 0%; text-align: left;\"><br><\/p><h4 style=\"text-align: left;\">Future event<\/h4><p class=\"\" style=\"text-align: left;\"><br><\/p><p class=\"last-child\"><span style=\"font-family: 'DM Sans', sans-serif\">For Pepper the next <\/span><strong><span style=\"font-family: 'DM Sans', sans-serif\">ESTIV <\/span><\/strong><span style=\"font-family: 'DM Sans', sans-serif\">(European Society of Toxicology <\/span><em><span style=\"font-family: 'DM Sans', sans-serif\">In Vitro<\/span><\/em><span style=\"font-family: 'DM Sans', sans-serif\">) congress (29 June- 2 July 2026, Maastricht) will be of key importance. This meeting is in Maastricht (NL) and is called: <\/span><em><span style=\"font-family: 'DM Sans', sans-serif\">Ensuring Safety, Advancing Science: Bridging to the Future with NAMs<\/span><\/em><span style=\"font-family: 'DM Sans', sans-serif\">. This aligns perfectly with the mission of Pepper to accelerate validation of NAMs in the ED space and with the scope of NAMWISE we are participating in. This will also be the best option to interact with many of our collaborators and friends from around Europe. If you are at the ESTIV meeting in June\/July please reach out to us for a meeting over coffee or seek us at our booth. We will update more on this during the spring on LinkedIn and at our homepage.<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b141\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"85%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:85%;width:85%;height:auto\" role=\"presentation\" data-testid=\"image-141\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/0bb155ac-c12d-7d62-e6ad-4d8a1577a64c.png\" width=\"520.1999999999999\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"141\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:20px;padding-bottom:20px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceDividerBlockContainer\" id=\"b138\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"background-color:transparent;width:100%\" role=\"presentation\" class=\"mceDividerContainer\" data-block-id=\"138\"><tbody><tr><td style=\"min-width:100%;border-top-width:2px;border-top-style:dotted;border-top-color:#d3e2ff;line-height:0;font-size:0\" valign=\"top\" class=\"mceDividerBlock\">\u00a0<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0\" valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-139\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"padding-top:0;padding-bottom:0;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" id=\"b139\"><table width=\"100%\" style=\"border:0;background-color:transparent;border-radius:0;border-collapse:separate\"><tbody><tr><td style=\"padding-left:48px;padding-right:48px;padding-top:10px;padding-bottom:5px\" class=\"mceTextBlockContainer\"><div data-block-id=\"139\" class=\"mceText\" id=\"d139\" style=\"width:100%\"><h1 style=\"text-align: justify;\"><strong>NAMWISE updates<\/strong><\/h1><p><br><\/p><p><br><\/p><p><span style=\"font-family: 'DM Sans', sans-serif\">This year was marked by the first in motion actions of the NAMWISE project Pepper is part of. \u00a0Pepper contributes to NAMWISE by leveraging its expertise in the validation of bioassays relevant to regulatory frameworks. As a public-private platform, Pepper helps bridge the gap between academic innovation and regulatory needs by selecting promising methods, ensuring reproducibility and transferability, and supporting their transition into internationally recognized guidelines such as those of the OECD.<\/span><\/p><p><span style=\"font-family: 'DM Sans', sans-serif\">To learn more about the project you can visit the website: <\/span><a href=\"http:\/\/www.namwise.eu\"><span style=\"font-family: 'DM Sans', sans-serif\">www.namwise.eu<\/span><\/a><\/p><p><br><\/p><p><span style=\"font-family: 'DM Sans', sans-serif\">You can also discover how NAMWISE mapped and analysed training resources on New Approach Methodologies (NAMs) across Europe: identifying key initiatives, audiences, and gaps to strengthen future education and capacity building >> <\/span><a href=\"https:\/\/namwise.eu\/content\/uploads\/2025\/10\/NAMWISE_Deliverable_D2.6_Mapping-of-training.pdf\" target=\"_blank\"><span style=\"font-family: 'DM Sans', sans-serif\">here<\/span><\/a><\/p><p class=\"mcePastedContent last-child\"><br><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"background-color:transparent;padding-top:12px;padding-bottom:12px;padding-right:24px;padding-left:24px;border:0;border-radius:0\" valign=\"top\" class=\"mceImageBlockContainer\" align=\"center\" id=\"b140\"><div><\/div><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"85%\" style=\"border-collapse:separate;margin:0;vertical-align:top;max-width:85%;width:85%;height:auto\" role=\"presentation\" data-testid=\"image-140\"><tbody><tr><td style=\"border:0;border-radius:0;margin:0\" valign=\"top\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/mcusercontent.com\/679c707fab1e7bd2bc8364edc\/images\/a7abb4d8-6d93-fa25-13e4-e8ba166bf75f.png\" width=\"520.1999999999999\" height=\"auto\" style=\"display:block;max-width:100%;height:auto;border-radius:0\" class=\"imageDropZone mceImage\" data-block-id=\"140\"><\/td><\/tr><\/tbody><\/table><div><\/div><div>\n\n<\/div><\/td><\/tr><tr><td valign=\"top\" class=\"mceGutterContainer\" id=\"gutterContainerId-71\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" style=\"border-collapse:separate\" role=\"presentation\"><tbody><tr><td style=\"background-color:#00a1d8;padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0;border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" id=\"b71\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"71\" id=\"section_b73c27320b01ebbc6421f7ee5eb2f4ec\" class=\"mceLayout\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\"><tbody><tr><td valign=\"top\" class=\"mceColumn\" 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All rights reserved.<\/span><\/em><span style=\"font-size: 12px\"><br>Nous vous envoyons cet e-mail, car vous vous \u00eates abonn\u00e9 via notre site Web.<br><br>Our mailing address is:<br>PEPPER\n22 Rue Charcot\nParis 75013\nFrance<br><br>Want to change how you receive these emails?<\/span><\/p><p class=\"last-child\"><span style=\"font-size: 12px\">You can <\/span><a href=\"https:\/\/ed-pepper.us2.list-manage.com\/profile?u=679c707fab1e7bd2bc8364edc&id=9bcab06e8f&e=[UNIQID]&c=6077818695\"><span style=\"font-size: 12px\">update your preferences<\/span><\/a><span style=\"font-size: 12px\"> or <\/span><a href=\"https:\/\/ed-pepper.us2.list-manage.com\/unsubscribe?u=679c707fab1e7bd2bc8364edc&id=9bcab06e8f&t=b&e=[UNIQID]&c=6077818695\"><span style=\"font-size: 12px\">unsubscribe<\/span><\/a><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><td style=\"border:0;border-radius:0\" valign=\"top\" class=\"mceLayoutContainer\" align=\"center\" id=\"b-2\"><table align=\"center\" border=\"0\" cellpadding=\"0\" cellspacing=\"0\" width=\"100%\" role=\"presentation\" data-block-id=\"-2\"><tbody><tr class=\"mceRow\"><td style=\"background-position:center;background-repeat:no-repeat;background-size:cover;padding-top:0px;padding-bottom:0px\" valign=\"top\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"24\" width=\"100%\" role=\"presentation\"><tbody><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/tbody><\/table>\n<\/td>\n<\/tr>\n<\/tbody><\/table>\n<\/center>\n<\/body><\/html>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud835\udde7\ud835\uddf5\ud835\uddf2 December 2025 \ud835\uddf2\ud835\uddf1\ud835\uddf6\ud835\ude01\ud835\uddf6\ud835\uddfc\ud835\uddfb \ud835\uddfc\ud835\uddf3 \ud835\udde1\ud835\uddf2\ud835\ude04\ud835\ude00\ud835\udde3\ud835\uddf2\ud835\uddfd\ud835\uddfd\ud835\uddf2\ud835\uddff \ud835\uddf6\ud835\ude00 \ud835\uddfb\ud835\uddfc\ud835\ude04 \ud835\uddf9\ud835\uddf6\ud835\ude03\ud835\uddf2! Dive into the latest on endocrine disruption, regulation, method validation, and Pepper\u2019s journey bridging research and regulatory impact. \ud83d\udd0d What\u2019s inside this issue:\ud83d\udea8 Policy spotlights\ud83d\udcc5 Events recap & upcoming\ud83e\uddea Pepper news \ud835\udde5\ud835\uddf2\ud835\uddee\ud835\uddf1 \ud835\ude01\ud835\uddf5\ud835\uddf2 \ud835\uddf3\ud835\ude02\ud835\uddf9\ud835\uddf9 \ud835\uddfb\ud835\uddf2\ud835\ude04\ud835\ude00\ud835\uddf9\ud835\uddf2\ud835\ude01\ud835\ude01\ud835\uddf2\ud835\uddff \ud835\uddf5\ud835\uddf2\ud835\uddff\ud835\uddf2: https:\/\/mailchi.mp\/ed-pepper\/newspepper_dec25-6254225Don\u2019t miss the next one, register NOW: https:\/\/lnkd.in\/eBDMhNWd NewsPepper: the […]<\/p>\n","protected":false},"author":5,"featured_media":8017,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52,51],"tags":[],"class_list":["post-8023","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newsletter","category-pepper-en"],"_links":{"self":[{"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/posts\/8023","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/comments?post=8023"}],"version-history":[{"count":2,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/posts\/8023\/revisions"}],"predecessor-version":[{"id":8025,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/posts\/8023\/revisions\/8025"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/media\/8017"}],"wp:attachment":[{"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/media?parent=8023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/categories?post=8023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ed-pepper.eu\/en\/wp-json\/wp\/v2\/tags?post=8023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}