Category: Uncategorized

Prepare to 𝗷𝗼𝗶𝗻 𝗣𝗲𝗽𝗽𝗲𝗿 𝗮𝘀 𝗮 𝗽𝗮𝗿𝘁𝗻𝗲𝗿 𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗼𝗿𝘆 engaged in validating methods for the characterization of #endocrinedisruptors.

This March we launch the call for “testing laboratories” for the #𝘃𝗮𝗹𝗶𝗱𝗮𝘁𝗶𝗼𝗻 of A 𝗡𝗘𝗪 𝗠𝗘𝗧𝗛𝗢𝗗 “TPO-CATALYZED IODINATION ASSAY”

Thyroid peroxidase (TPO) is an enzyme in thyroid follicular cells that uses hydrogen peroxide to iodinate thyroglobulin, producing MIT, DIT, and ultimately the hormones T3 and T4. The method measures the TPO activity and assesses the possibility of test chemicals to inhibit TPO.

To apply, send your offer no later than the10th of April, following the instructions on the attached document to tender@ed-pepper.eu
📨 If you have questions, please do not hesitate to contact us!

🔬 Pepper 2025: Call for Endocrine Disruption Test Methods 🔬

Every year, Pepper supports the validation of innovative test methods for endocrine disruption — and the 2025 selection round is now open!

We invite public and private laboratories to submit methods that:
✅ Demonstrate high technological maturity (solid written protocol and sufficient data — see ReadEDtest)
✅ Address regulatory needs (especially for modes of action currently lacking validated tests)
✅ Fit into integrated assessment strategies
✅ Show strong potential for dissemination across laboratories
✅ Present no legal or logistical barriers

🚫 Please note:

• In silico methods
• Methods outside the 3R framework
• Methods already undergoing validation
• Methods duplicating existing validated tests
  are not eligible.

📅 Deadline for submission: 31 August 2025
🗓 Selection: October 2025 (by the Pepper Relevance Committee) 💡

Submit your method and contribute to the future of endocrine disruption testing: https://ed-pepper.eu/wp-content/uploads/2025/06/Call-for-methods-2025-1.docx

We’re thrilled to share a milestone edition of our newsletter — now delivered via Mailchimp, in a fresh format with the same trusted expertise !

👉 Dive into the full newsletter here : https://urlr.me/AVKZYh

Here’s a glimpse of what’s inside:

👩‍🔬 Want to meet our new CEO ?
Céline Boudet has officially joined Pepper ! With 25+ years in environmental health and toxicology, she’s bringing bold leadership to drive scientific excellence and regulatory impact.

🌐 What did we learn at SOT 2025 ?
From DNT to endocrine disruption, the Society of Toxicology meeting in Orlando highlighted the global momentum for NAMs.

🔬 How is Europe advancing New Approach Methodologies ?
Get the inside track on Pepper’s role in NAMWISE, ValNAM, and strategic EU initiatives shaping the future of innovative regulatory science.

📚 How do you manage a method validation project ?
Our first hands-on training course brought together experts to build real-world validation skills. See what’s next and how to join!

🎤 What’s next on the calendar ?
We’re heading to key scientific events this summer. Plus, find out how we’re contributing to France’s national strategy on endocrine disruptors.

And more!

PDF version:

Pepper was pleased to participate in the 64th Society of Toxicology (hashtag#SOT2025) Annual Meeting in Orlando. Our Director, Philippe Hubert, contributed to a Continuing Education session focused on the development and regulatory alignment of New Approach Methods (NAMs). Below is a document that summaries impressions and insights from the event.

At Pepper, we are committed to advancing the professionalization of method validation. We recently had the privilege of providing specialized training to a member of the German Federal Institute for Risk Assessment (BfR) on validation principles. This session was delivered by our expert, Andrea Rivero Arze, PhD (Ecotoxicologist), and marks a significant step in our long-term collaboration.

We appreciate BfR’s trust in us as a partner in this journey. This training serves as a foundation for future cooperation, supporting efforts to enhance expertise in method validation.

At Pepper, we believe that validation should be a professional competency, and we are dedicated to equipping experts with the knowledge they need. As part of this commitment, we now offer on-demand training for professionals looking to integrate validation into their careers.

If you are interested in advancing your expertise in validation, feel free to reach out to us.
✉️ contact@ed-pepper.eu

Prepare to 𝗷𝗼𝗶𝗻 𝗣𝗲𝗽𝗽𝗲𝗿 𝗮𝘀 𝗮 𝗽𝗮𝗿𝘁𝗻𝗲𝗿 𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗼𝗿𝘆 engaged in validating methods for the characterization of endocrine disruptors.

We are happy to announce the call for “testing laboratories” for the hashtag#𝘃𝗮𝗹𝗶𝗱𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 2 𝗡𝗘𝗪 𝗠𝗘𝗧𝗛𝗢𝗗𝗦 “Peroxisome Proliferator-Activated Receptor γ Transactivation Assay (PPARγ-TA)” and “Progesterone Receptor Transactivation Assay (PR-TA)”.

ℹ️: 𝘛𝘩𝘦 𝘢𝘱𝘱𝘭𝘪𝘤𝘢𝘵𝘪𝘰𝘯 𝘱𝘳𝘰𝘤𝘦𝘴𝘴𝘦𝘴 𝘧𝘰𝘳 𝘵𝘩𝘦 𝘵𝘸𝘰 𝘮𝘦𝘵𝘩𝘰𝘥𝘴 𝘢𝘳𝘦 𝘪𝘯𝘥𝘦𝘱𝘦𝘯𝘥𝘦𝘯𝘵. 𝘓𝘢𝘣𝘴 𝘮𝘢𝘺 𝘢𝘱𝘱𝘭𝘺 𝘧𝘰𝘳 𝘰𝘯𝘦 𝘰𝘳 𝘣𝘰𝘵𝘩 𝘮𝘦𝘵𝘩𝘰𝘥𝘴 𝘴𝘦𝘱𝘢𝘳𝘢𝘵𝘦𝘭𝘺.

To apply, send your offer no later than the 20𝘁𝗵 𝗼𝗳 𝗔𝗽𝗿𝗶𝗹, following the instructions on the attached document to philippe.hubert@ed-pepper.eu and to torben.osterlund@ed-pepper.eu.

➡️ You can also reach out to Philippe in person if you are at the SOT in Orland (16-20 March).

📨 If you have questions, please do not hesitate to contact us!

Last December, we celebrated PEPPER’s 5th anniversary!
On this occasion, Philippe Hubert (Director), Philippe Prudhon (President), and Ella Atlas (President of the Scientific Council), shared their views on the evolution of the project, its major achievements and future prospects for Pepper and method validation.